Autoimmune Hemolytic Anemia

- Definition AIHA : caused by premature destruction of red blood cells antibody induced hemolysis.

- Happen : Idiopathic , in any age , the rate of female more than male .

- Laboratory test : Coombs test . 

• Blood film . 
• CBC ( Complete Blood Count ) . 
• Chemistry .

- AIHA divided tow Group : 

• Warm : IgG attacks red blood cells patients are usually over age 50 treated with corticosteroids . 
• Cold : IgM and complement coat red blood cells and trigger hemolysis patients usually over age 50 sometimes resolves with cold avoidance rarely progresses to renal failure .

- Sign symptoms : 

• Some time Patient with AIHA have no symptoms . 
• fatigue . 
• weakness . 
• paleness . 

- Treatment :

• Corticosteroid . 
• If happen by drug treated by Immune Globulin . 
• When no response to Corticosteroid surgical intervention ( Splenectomy ) . 
• When no response after Splenectomy giving Cyclosporine .

Aplastic Anemia

- Definition : Its problem in Bone marrow become production not enough Plasma cell ( White blood cell , Red blood cell , Platelet ) .

- happen: suddenly , in any age .

- Sign symptoms :

• Fatigue . 
• high risk inflammation . 
• bleeding . 
• Pallor.

-Diagnosis: CBC ( complete blood count ) .
Full Chemistry ( LDH , Kidney function , Liver function , Bilirubin ) and Other laboratory test .

- Pharmacotherapy :

• Immunosuppressive agents example (cyclosporine, methylprednisolone, equine antithymocyte globulin, rabbit antithymocyte globulin, cyclophosphamide, alemtuzumab) . 
• Hematopoietic growth factors example ( eltrombopag, sargramostim, filgrastim) . 
• Antimetabolite example (purine) antineoplastic agents ( fludarabine). 
• Chelating agents example ( deferoxamine, deferasirox) .

- Non Pharmacotherapy :

• Supportive care . 
• Blood transfusions . 
• Hematopoietic cell transplantation .

Multiple Myeloma

 That Cancer of Plasma cell happened in Bone Marrow , produce abnormal proteins that can affected to all body organ specially bone and cause kidney problems , associated with severe Back Pain and Both leg Pain Patient with this Disease easy to happen fracture with any mistake move .

Treatment of this Patient different from Patient to other some time victim response on THALIDOMIDE  that must taken before it Anticoagulant because maybe happened Thrombosis .
Another pt response on VELCADE and other chemotherapy .

Tips Protect your Breast Cancer

There are a set of tips that will reduce the risk of this type of cancer, and increases the likelihood of being detected happens In case at an early stage so that it is then easier to treat  Breast feeding baby naturally, Keep a healthy weight.

Being active, and Doing Sports  Do not drink alcohol and do not smoke. See your doctor regularly.
Limit the use of hormone therapy for menopause